Objective To understand the current status of ethical behavior among oncology nurses, and to analyze its influencing factors, so as to provide a reference for developing targeted intervention.Methods A total of 552 oncology nurses from three tertiary hospitals in Zhengzhou were selected by using convenience sampling method, then they were surveyed by utilizing a general information questionnaire, the Ethical Behavior Scale for Nurses-Revise (EBSN-R), the Rushton Moral Resilience Scale (RMRS) and the Hospital Ethical Climate Survey (HECS).Results The total score of the EBSN-R among oncology nurses was (75.85±10.75).Multiple linear regression analysis showed that, years of working experience, the score of RMRS and HECS were the main factors affecting the ethical behavior of oncology nurses (all P＜0.05), which explained 50.0% of the total variance.Conclusion Ethical behavior among oncology nurses is at a medium and above level.Nursing managers can improve oncology nurses′ ethical behavior by enhancing their moral resilience and creating a good hospital ethical climate.