Objective To explore the application effect of rehabilitation training program in patients with limited shoulder joint mobility due to implantable venous access port (IVAP). Methods Patients with limited shoulder joint mobility due to IVAP was selected as the study subjects. Sixty-nine patients were assigned to the control group and received conventional grip strength ball training, while 72 patients were assigned to the intervention group and received rehabilitation training. After 3 months, shoulder joint mobility, activities of daily living (ADL) ability, and the incidence of complications were compared between the two groups. Results After intervention, the scores for shoulder joint mobility (flexion, abduction, external rotation, internal rotation, extension) and ADL ability in both groups improved significantly compared to the scores before intervention.The intervention group showed significantly better scores than the control group after intervention, and the incidence of thrombosis was significantly lower than that of the control group (all P<0.05). There was no significant difference in the occurrence of catheter blockage and displacement between the two groups (all P>0.05). Conclusion The rehabilitation training program is simple, easy to learn and master, without limitations on location and time. It can improve the shoulder joint range of motion and ADL ability in patients with limited shoulder joint mobility due to IVAP and reduce the incidence of thrombosis.