Objective To analysis of the impact of family resilience on the fear of progression in stroke patients and their spousal caregivers based on the subject-object interdependence model. Methods A total of 381 couples of stroke patients and their spouses (main caregivers) were surveyed using the general data questionnaire, Fear of Progression Questionnaire-Short Form (Fop-Q-SF), Fear of Progression Questionnaire-Short Form/Partner Version (FoP-Q-SF/P), and Family Resilience Questionnaire (FaRE). A subject-object interdependence model of resilience′s impact on the fear of disease progression was established. Results The fear of progression score of stroke patients (31.59±10.37) was significantly higher than that of spousal caregivers (29.68±11.24) (P<0.05). In terms of the subjective effect, the family resilience level of stroke patients and their spouses could affect their own fear of progression (P<0.05 for borh). Regarding the object effect, the patient′s fear of progression was affected by the family resilience level in their spouses (P<0.05), while the spouse′s fear of progression was affected by the family resilience level in patients (P<0.05). Conclusion The levels of fear of progression in stroke patients and their spouses have interactive effects with their family resilience levels. This suggests that nurses can develop interventions based on the dual perspective of patients and their spouses′ family resilience to effectively reduce their fear of progression.