Objective To explore the application effect of the curriculum ideological and political education scheme for the Basic Nursing course, which uses life education as an entry point, on enhancing nursing students′ sense of life meaning and professional identity. Methods A total of 95 students from two parallel classes of 2021 nursing undergraduate in a certain university were selected as the research subjects, and they were divided into the experimental class (n=49) and the control class (n=46). The nursing students in the control class adopted the conventional curriculum ideological and political education method, while the experimental class implemented the curriculum ideological and political education scheme of Basic Nursing course with life education as the entrypoint. Two classes of nursing students were investigated before, during and after teaching on the sense of life meaning and professional identity. Results After the course, the total scores of the sense of life meaning and professional identity in the experimental class were significantly better than those in the control class (all P<0.05). Moreover, these scores were significantly higher than those before the teaching (all P<0.05). Conclusion The curriculum ideological and political education in the Basic Nursing course, with life education as the entry point, can effectively enhance nursing students′ sense of life meaning and professional identity.