Objective To systematically review and synthesize nurses′ experiences of utilizing mobile health(mHealth) in chronic disease management, and to provide references for improvement of mHealth service. Methods Such databases as Medline (Ovid),Embase,Cochrane Library,Web of Science,CINAHL, CNKI, Wanfang Data and VIP were searched to collect qualitative studies on nurses′ experiences of utilizing mHealth in chronic disease management. The search time frame was limited from database inception to February, 2023. The quality of included studies was evaluated according to JBI Critical Appraisal Tool for qualitative studies. Meta-synthesis was used to integrate results. Results A total of 8 studies were included to extract 66 research results, which were later grouped into 10 categories; then the 10 categories were further factored into 2 synthesized findings:the perceived benefits of nurses in using mHealth for chronic disease management;the perceived barriers of nurses in using mHealth for chronic disease management. Conclusion mHealth is helpful for nurses to manage patients with chronic diseases, but there are still some barriers in its use. Measures should be taken from the aspects of usability improvement, the integration of mHealth and traditional management services, and refinement in relevant policies.