Objective To investigate the feasibility of paraumbilical winding fixation of umbilical venous catheter in newborns. Methods In the prospective quasi-experimental design, 145 newborns who were to receive umbilical vein catheterization were divided into 2 groups in order of hospitalization. After successful umbilical vein catheterization, the control group (n=67) was subjected to routine closed periumbilical winding fixation of umbilical venous catheter, while the intervention group (n=78) was subjected to paraumbilical winding fixation. The total catheter retention time, the counts of film replacement, the incidence rate of catheter displacement and umbilical complications were compared between the two groups. Results The total catheter retention time in the intervention group were significantly longer than in the controls; the counts of film replacement were fewer, the incidence rate of catheter displacement and umbilical complications in the former than those in the latter(all P.<0.05). Conclusion Paraumbilical winding fixation of umbilical venous catheter in newborns can effectively reduce the frequency of film replacement and the incidence rate of complication, and effectively extend catheter retention time.