Objective To reduce medical adhesive related skin injury (MARSI) in infants and young children′s scalp during video EEG monitoring (VEEG). Methods Using a historical controlled design, 856 children admitted to the epilepsy monitoring unit from January 2018 to December 2019 who underwent scalp VEEG were included in the control group and received routine skin care; 851 children from January 2021 to December 2022 were included in the experimental group, and an MARSI nursing and prevention plan was implemented. The incidence rate of scalp MARSI between two groups was compared. Results The incidence rate of scalp MARSI in the experimental group was significantly lower than that in the control group (P.<0.05). Conclusion The nursing and prevention plan can effectively reduce the incidence rate of scalp MARSI infants and young children.