Objective To investigate the level and factors associated with oral frailty among hospitalized cancer patients, and to provide references for targeted interventions.Methods A total of 207 hospitalized cancer patients were selected using convenience sampling and invited to complete a battery of questionnaires, including a general information questionnaire, the Oral Frailty Index-8, the Oral Health Assessment Tool, the Nutritional Risk Screening 2002, the FRAIL Scale and the Perceived Social Support Scale.Results The prevalence of oral frailty in hospitalized cancer patients was 64.3%.Age, smoking history, history of chemotherapy, dry mouth, denture, poor oral health, and physical frailty were the influencing factors of oral frailty in hospitalized cancer patients （all P＜0.05）.Conclusion Oral frailty is prevalent in hospitalized cancer patients.Interventions should be targeted to the influencing factors, in an effort to avoid or control the development of oral frailty.