Objective To improve the efficiency and accuracy of venous thromboembolism (VTE） assessment and reduce the occurrence of VTE in orthopedic patients.Methods A total of 2,586 orthopedic patients were divided into a control group of 1,023 and an observation group of 1,563 chronologically.The control group was used paper-form assessment for possible risk of VTE and the results were manually input into the Hospital Information System, while the observation group received VTE risk management by using a self-designed AI-based system.Results The performance of the system used in the observation group was more efficient and accurate compared with earlier methods in the control group (both P＜0.05).The observation group had significantly higher satisfaction of medical staff, whereas significantly lower incidence of VTE compared with the control group （both P＜0.05）.Conclusion The application of AI-based system for VTE prophylaxis in orthopedic patients can effectively improve the efficiency and accuracy of VTE assessment, reduce the occurrence of VTE, and enhance job satisfaction of medical staff.