Objective To understand the current situation of nausea and vomiting in patients undergoing fecal microbiota transplantation, and to analyze its influencing factors, so as to provide a reference for conducting targeted nursing intervention. Methods A total of 311 patients undergoing fecal microbiota transplantation were cross-sectionally investigated by using a general information questionnaire, the cognitive questionnaire of fecal microbiota transplantation, and the Connor-Davidson Resilience Scale. Results The incidence of nausea and vomiting in the participants was 19.61%. Logistic regression analysis showed that, age, times of transplantations, cognition of transplantation and resilience were the main influencing factors of nausea and vomiting in patients undergoing fecal microbiota transplantation (all P<0.05). Conclusion Patients undergoing fecal microbiota transplantation are prone to suffer from nausea and vomiting, it is necessary to strengthen health education and nursing intervention according to its influencing factors, so as to reduce the incidence of nausea and vomiting, and improve patients′ treatment experience.