Objective To investigate the current situation of symptom distress in nasopharyngeal carcinoma patients experiencing chemoradiotherapy induced chronic sinusitis, and analyze its influencing factors, so as to provide a reference for developing relevant nursing countermeasures. Methods A total of 193 nasopharyngeal carcinoma patients experiencing chemoradiotherapy induced chronic sinusitis were selected in the outpatient clinic of radiotherapy department of a tertiary general hospital in Guangxi by conve-nience sampling method, then they were cross-sectionally investigated by utilizing a general information questionnaire, the Sino-Nasal Outcome Test, the Consumer Health Activation Index, and the Chinese version Prognosis and Treatment Perception Questionnaire. Finally, multiple linear regression analysis was conducted to analyze the influencing factors of the participants′ symptom distress. Results The participants scored (27.05±6.37) in symptom distress. Multiple linear regression analysis showed that, nasopharyngeal flushing compliance, health positivity score, and prognostic concern score were predictors of symptom distress in nasopharyngeal carcinoma patients experiencing chemoradiotherapy induced chronic sinusitis (all P<0.05). Conclusion Symptom distress in nasopharyngeal carcinoma patients experiencing chemoradiotherapy induced chronic sinusitis is at a mild level and prevalent. It is urgent for medical staff to develop targeted nursing interventions to alleviate patients′ burden of symptoms, and improve their quality of life.