Objective To construct a spousal synchronous empowerment intervention scheme for tongue cancer patients after surgery, and to verify its application effect. Methods Based on the theory of empowerment, a spousal synchronous empowerment intervention scheme was constructed through literature review and expert meetings, which included clarifying problems, expressing emotions, constructing a scheme, implementing the scheme, and evaluating intervention effect. Fifty-four tongue cancer patients after surgery were selected and divided into an intervention group and a control group by coin toss method, with 27 cases in each group. The control group hospitalized in ward Ⅱ and was given routine postoperative care, the intervention group hospitalized in wardⅠand additionally received the spousal synchronous empowerment intervention scheme, lasting three months. The swallowing function, feeding function and self-efficacy between the two groups were compared before the intervention, 2 weeks, 1 month and 3 months after the intervention. Results At 2 weeks, 1 month and 3 months after the intervention, the scores of swallowing function, feeding function and self-efficacy of the intervention group were significantly better than those of the control group (all P<0.05), and the intervention effect, time effect and intervention×time effect in the above scores were statistically significant between the two groups (all P<0.05). Conclusion Application the spousal synchronous empowerment intervention scheme in tongue cancer patients after surgery can effectively enhance their self-efficacy, improve their swallowing function and promote early recovery.