Objective To develop a home-based rehabilitation program for patients receiving total knee arthroplasty (TKA) and to promote home management.Methods Guided by the Knowledge-to-Action framework, the development of home-based rehabilitation protocol involved such steps:first step, systematic literature review and quality assessment of relevant studies on home-based rehabilitation after TKA were performed; second step, the best evidence was extracted and summarized to generate rehabilitation contents; third step, two rounds of expert consultation were conducted using the Delphi method to determine the most appropriate rehabilitation contents; fourth step, qualitative interviews with patients, practitioners, and managers, were conducted to better understand facilitators and barriers of evidence implementation; and the last step, action strategies were formulated by an expert panel.Results A total of 23 articles were included, Twenty four items of rehabilitation contents were selected for home-based rehabilitation and a detailed protocol across postoperative weeks 2-26 was formulated.Three facilitators and four bar-riers were identified. A home-based rehabilitation program and a flowchart for the assessment and implementation of the program were developed.Conclusion Following the Knowledge-to-Action framework, the home-based rehabilitation program, which incorporates the best evidence and considers professional judgments, patient preferences, and available resources, can offer standardized and systematic intervention guidelines for patients engaging in home-based rehabilitation exercises.