Objective To investigate the level of kinesiophobia among patients after percutaneous coronary intervention (PCI) and to explore the latent profiles of kinesiophobia and their relationships with physical activity.Methods A total of 328 patients after PCI were selected using convenience sampling method and were asked to complete a general information questionnaire, the Tampa Scale for Kinesiophobia Heart, and the International Physical Activity Questionnaire.Latent profile analysis was performed to identify potential profiles and ordinal logistic regression was used to determine the factors influencing physical activity.Results The sample scored 40.74±5.40 on kinesiophobia.Latent profile analysis revealed three distinct groups:low kinesiophobia-high adaptive （15.2%）, medium kinesiophobia-borderline （50.6%） and high kinesiophobia-avoidance （34.2%）.The work or retirement statuses, NYHA heart function grade, physical exercise behavior before the surgery and profiles of kinesiophobia were factors affecting physical activity grade （all P＜0.05）.Conclusion There are possible heterogeneous nature of kinesiophobia among patients after PCI and the profiles of kinesiophobia affect physical activity.Our findings underscore the importance of designing and implementing interventions by profiles of the patients in promoting physical activity behavior.