Objective To explore the efficacy of hypnotherapy in adolescent depression.Methods Seventy adolescents with depression were assigned to two groups according to admission sequence, with 35 in each group.The control group were given routine psychological care, while the intervention group additionally received hypnotherapy once a week for ten weeks.The Self-rating Depression Scale （SDS）, the Difficulties in Emotion Regulation Scale (DERS) and the Emotion Reactivity Scale （ERS） were completed by the participants at three points:before, immediately after, and 1 month after the intervention.Results The DERS score immediately after the intervention, as well as the scores of SDS, DERS, and ERS 1 month after the intervention, had significant differences between the two groups （all P＜0.05）.Conclusion Hypnotherapy can effectively improve emotion regulation ability of adolescents with depression and alleviate depression.