This paper summarizes the origins, concepts, and development of ICU liaison nurses, elaborates the entrance qualifications, training and assessment procedures, work pattern and roles of ICU liaison nurses. The contents of ICU liaison nurses in clinical practice include participating in medical decisions of transferring to and from the ICU, coordinating and organizing transfers, standardized handover, providing follow-up, education and support after transfers. It is recommended to explore and establish Chinese culture suitable training programs, entry qualification, and management strategies for ICU liaison nurses.