Objective To evaluate the intervention effects of dual-task training based on serious games for older adults with mild cognitive impairment (MCI) residing in nursing homes. Methods Sixty older adults with MCI from nursing homes were divided into a control group (n=30) and an intervention group (n=30) based on their place of residence. The control group received conventional care and recreational activities, while the intervention group additionally received a 12-week dual-task training program consisting of tablet games based on serious games and aerobic exercises. Results A total of 25 participants in the intervention group and 26 participants in the control group completed the study. After the intervention, the Geriatric Depression Scale score in the intervention group was statistically significant lower than that of the control group, and its scores of the Montreal Cognitive Assessment and the physical and psychological domains of the short form Quality Life Scale were statistically significant higher than those in the control group (all P＜0.05). While there was no statistically significant difference in the scores of the Activity of Daily Living Scale between the two groups (P＞0.05). Conclusion Dual-task training based on serious games is beneficial for improving cognitive function for older adults with MCI in nursing homes, alleviating their depressive symptoms, and enhancing their quality of life.