Objective To understand the status of self-regulatory fatigue and analyze its influencing factors in convalescent stroke patients, so to provide a reference for developing tailored interventions. Methods A total of 330 convalescent stroke patients were investigated by utilizing a general information sheet, the Self-regulatory Fatigue Scale (SRF-S), the Stroke Patients′ Symptom Experience Scale (stroke-SES) , the Social Support Rate Scale (SSRS), and the Medical Coping Modes Questionnaire (MCMQ). Results The participants′ SRF-S score was 51.88±4.84. The stepwise multivariate linear regression analysis showed that,the time from onset to investigation, number of chronic diseases, self-care ability, disease awareness,symptom burden, social support, and avoidance coping mode were major influencing factors of self-regulatory fatigue in convalescent stroke patients (all P<0.05), which explained 78.6% of its total variance. Conclusion The level of self-regulatory fatigue in convalescent stroke patients is high. Medical staff should assess convalescent stroke patients′ self-regulatory fatigue periodically, and develop tailored intervention measures according to the identified influencing factors, so as to reduce patients′ self-regulatory fatigue.