Objective To construct and implement a family resilience intervention program for caregivers of first-stroke patients, and to evaluate itsapplication effect. Methods Based on literature study, delphi expert consultation and a pilot study, a family resilience intervention program for caregivers of first-stroke patients was constructed. Eighty-one caregivers offirst-stroke patients were divided into a control group (n=41) and an intervention group (n=40) chronologically. The control group received routine nursing, while the intervention group additionally received the family resilience intervention program for caregivers of first-stroke patients. The scores of the Shortened Chinese Version of Family Resilience Assessment Scale (FRAS-C), the Stroke Caregivers′Comprehensive Care Ability Scale and the Zarit Caregiver Burden Interview(ZBI) were compared between the two groups before the intervention, 1 month and 3 months after the intervention. Results After the intervention, the scores of the FRAS-C and the Stroke Caregivers′ Comprehensive Care Ability Scale in the intervention group were significantly higher than those in the control group, while its score of ZBI was significantly lower than that in the control group (all P<0.05). Conclusion The family resilience intervention program for caregivers of first-stroke patients can significantly improve the family resilience and comprehensive care ability of caregivers, and reduce their care burden.