Objective To explore the application effect of a graded physical restraint regimen in severe neurologic patients, so as to provide a reference for clinical nursing. Methods A total of 209 severe neurologic patients were divided into a control group （n=101） and an intervention group （n=98） according to admission branch of a hospital.The control group received the conventional physical restraint scheme, while the intervention group adopted a graded physical restraint regimen.The physical restraint rate, physical restraint time, unplanned extubation rate, incidence of delirium and satisfaction of patients or their family members were compared between the two groups. At the same time, the nurses providing care for the two groups (38 nurses for each group) were selected to compare their physical restraint knowledge and behavior before and after related training. Results There were significant differences in the physical restraint rate, physical restraint time, incidence of delirium and satisfaction of patients or their family members between the two groups （all P＜0.05）, while there wasn′t significant difference in unplanned extubation rate between the two groups （P＞0.05）.After the training, the nurses′ total scores of physical restraint knowledge and behavior in the intervention group were significantly higher than those in the control group （both P＜0.05）. Conclusion Practice of the graded physical restraint regimen can reduce the physical restraint rate, shorten the restraint time and decrease the incidence of delirium in severe neurologic patients. It is beneficial to improve nurses′ knowledge and capacity of physical restraint, then increase the satisfaction of patients and their family members, and ensure patients′ restraint safety and comfort at last.