Objective To summarize the nursing experience of postoperative hypoxaemia in obese patients with Stanford type A aortic dissection, so as to provide a reference for clinical nursing. Methods A total of 41 obese patients with Stanford type A aortic dissection who suffered from hypoxaemia after cardiac surgery were selected, their nursing interventions included lung protective ventilation strategy and prone position ventilation, closely condition observation, delirium prevention strategy, and early rehabilitation nursing for hypoxaemia. Results Hypoxaemia improved in all the 41 patients, 36 of them were successfully transferred out of the cardiac intensive care unit and discharged, and the other 5 patients were transferred to other hospitals to continue rehabilitation treatment because of incomplete recovery of limb muscle strength.Their length of hospitalization was 5-52（20.7±8.6） days, and their stay in ICU was 40 to 851 hours, the median of which was 247 hours, and the time of mechanical ventilation assistances was 16-710 hours, and its median was 181 hours. Conclusion The incidence of postoperative hypoxaemia in obese patients with Stanford type A aortic dissection is high, and it is significant to monitor the patients′ condition change closely after surgery, and take targeted interventions as early as possible, so as to correct their hypoxaemia, get off the ventilator as soon as possible, and improve their clinical prognosis.