Objective To systematically evaluate the effect of couple-centered psychological intervention on the psychological status of pregnant and postpartum women. Methods PsycINFO, PubMed, Embase, CINAHL, Web of Science, The Cochrane Library, CNKI, and Wanfang Database were searched for randomized controlled trials (RCT) that examined the effects of couple-centered psychological interventions on the psychological status of pregnant and postpartum women.Meta-analysis was conducted using RevMan 5.4 software, and sensitivity and subgroup analyses were performed to explore potential sources of heterogeneity and assess the robustness of the results. Results A total of 17 studies involving 3,123 pregnant and postpartum women were included. The results of Meta-analysis showed that the couple-centered psychological intervention significantly reduced the incidence of depressive symptoms ［RR=0.45,95%CI(0.33,0.60),P＜0.05］, and reduced the levels of depression, anxiety and stress of pregnant and postpartum women (all P＜0.05).The subgroup analysis based on the intervention span showed that there were significant differences in depression and anxiety scores between the intervention group before delivery, the groups before and after delivery and the control group (all P＜0.05). Conclusion The couple-centered intervention has a positive effect on improving the depression, anxiety and stress status of pregnant and postpartum women.But due to the heterogeneity among studies, the effect size needs further verification through large sample size, multi-center and high-quality RCTs.