Objective To develop review indicators for prevention of bleeding after endoscopic mucosal lesion treatment ,and to conduct a clinical on-the-site review. Methods Using the Ottawa Model of Research Use （OMRU） as a theoretical framework, we identified clinical care problems, formed an evidence-based care team, systematically searched the literature, appraised the quality of included literature, and summarized the evidence.Then we developed review indicators and review methods.After conduct a clinical on-the-site review, we analyzed barriers and facilitators to the introduction of evidence into clinical setting from 3 perspectives based on the review results:evidence-based transformation, potential adopters, and practice environment.At last, we developed countermeasures for further action. Results A total of 26 pieces of best evidence were included, and 30 review indicators were developed; 14 review indicators had an adherence rate ＞60%, 16 review indicators had an adherence rate ＜60% (among them, 14 indicators had an adherence rate of 0) .The main barriers were the complexity of the evidence content and the lack of evidence translation into an accessible form for nurses, the lack of evidence-based knowledge of health care workers, the lack of evidence standardized process flows in multi-form health education materials, and the lack of multidisciplinary cooperation mechanisms.The main facilitators were the improvement of evidence-based project management system, the strong willingness to change at the managerial level, and health care workers′ willingness to innovate. Conclusion There is a large gap between the evidence for the management of bleeding after endoscopic mucosallesion treatment, and clinical practice.Health care workers are recommended to fully utilize the facilitators, overcome the barriers, and implement improvement schemes, in a bid to promote the effective application of the evidence.