Objective To investigate the status of stigma for seeking professional psychological help among perinatal women and analyze the influencing factors. Methods A total of 517 perinatal women were enrolled and completed the general information questionnaire, the Questionnaire of Stigma for Seeking Professional Psychological Help （SSPPH）, the Edinburgh Postnatal Depression Scale （EPDS）, the Self-Esteem Scale （SES） and the Multiple Mental Health Literacy Measure （MMHLM）.Multiple stepwise linear regression model was used to analyze the influencing factors of stigma for seeking professional psychological help. Results The perinatal women scored （21.16±6.10） points in stigma for seeking professional psychological help.Multiple stepwise linear regression analysis results showed that depression, self-esteem, mental health literacy were influencing factors of stigma for seeking professional psychological help （all P＜0.05）. Conclusion The level of stigma for seeking professional psychological help among perinatal women was slightly below medium level.Diverse and targeted measures were should be taken at individual, family, and health care worker level, in a effort to reduce the level of stigma for seeking professional psychological help among perinatal women, and facilitate maternal and infant health.