Objective To construct a consultation platform for difficult intravenous therapy (IV) access in a children′s specialized hospital and to explore its application effect. Methods We established an IV team comprising a chief IV therapist and several IV specialist nurses, and provided intra- or out-of- hospital consultation service for children with difficult IV access. Results After implement of the platform based consultation service, the number of IV specialist nurses saw a surge from 8 to 33; the counts of intra-or out-of- hospital consultation service,and satisfaction of children′s family members with consultation service also saw a significant hike. Conclusion The construction and application of the consultation platform for difficult IV access in children′s specialized hospital, is conducive to enhancing the quality and efficiency of clinical consultation service, meet individual needs of children and improve satisfaction of children′s family.