In 126 cases of metastatic colorectal cancer patients treated with combination regimen,37 cases (29.37%) developed adverse drug reactions, including 10 cases of skin toxic reactions, 10 cases of gastrointestinal reactions, 8 cases of fatigue, 4 cases of oral mucositis, 3 cases of hypertension, and 2 cases of thrombocytopenia.The cases were closely observed, accurately graded, and targeted nursing measures were implemented according to the gradings.After timely detection and treatment, 22 patients′ symptoms were relieved and combination treatment was successfully completed, while 15 cases terminated or aborted treatment.