Objective To explore the method and effect of designing high-fidelity simulation training course for doctor-nurse cooperation based on the Fink model. Methods A total of 28 nursing students and 16 clinical medical students were recruited as course attendees.A high-fidelity simulation training course for doctor-nurse cooperation was designed based on the Fink model.Eight high-fidelity simulation teaching cases were incorporated into the scenario-based simulation teaching, with each case consisting of 4 hours of instruction, totaling 32 hours. Results After teaching, the students scored （80.06±5.38） points for the course; the total score of doctor-nurse cooperation attitude and the scores of 3 dimensions, as well as the total score of critical thinking ability and the scores of 5 dimensions were significantly higher than before teaching （all P＜0.05）.The interview results showed that this course was conducive to the cultivation of students′ such abilities as doctor-nurse cooperation, problem finding, problem analyzing & solving, and communication. Conclusion The teaching of high-fidelity simulation training course for doctor-nurse cooperation is helpful to enhance students′ academic performance, improve their attitude towards and ability of doctor-nurse cooperation, as well as clinical thinking ability.