Objective To explore the latent classes of work immersion experiences in nursing interns and its relationship with career adaptability, so as to provide a reference for nursing clinical teaching. Methods A total of 169 nursing interns from 10 tertiary general teaching hospitals in Wuhan were selected and investigated by using a general information questionnaire, the Work Immersion Experience Scale and the College Student Career Adaptability Scale, then the data were analyzed by latent profile analysis. Results The participants′ work immersion experiences could be divided into four latent classes:low level immersion group （12.3%）,medium to low level immersion group （55.6%）, medium to high level immersion group （28.4%） and high level immersion group （3.6%）.There were statistically significant differences in distribution of the 4 groups by interns′ love degree of nursing specialty, and monthly living expenses; there were also significant differences in career adaptability and each subscale scores among the four groups （all P＜0.05）. Conclusion There are four latent classes of work immersion experiences in nursing interns with demographic differences, and the level of work immersion experiences affects their adaptability to nursing career.It is necessary to take targeted intervention according to the heterogeneity of the interns′ work immersion experiences, so as to help them improve work immersion experiences and enhance career adaptability ultimately.