Objective To explore the symptom group and quality of life of breast cancer patients during dual-target therapy, and to provide guidance for effective symptom management of breast cancer. Methods Using cross-sectional research methods,185 female patients with HER-2 positive breast cancer were investigated with General information questionnaire, the Chinese version of the Memory Symptom Assessment Scale and the Chinese version of the breast cancer patients′ quality of life scale. Results Four symptom groups were extracted by principal component analysis, which were named as skin and mucosa symptom group,gastrointestinal symptom group,emotional symptom group and neurological symptom group.The average score of quality of life of breast cancer patients was (100.01±14.76), and the symptom group was negatively correlated with the quality of life of patients. Multiple linear regression analysis showed that the quality of life was affected by age,family monthly income,economicstatus,maritalstatus,pathological stage, hormone receptor status and symptom group (all P<0.05). Conclusion Breast cancer patients have a variety of symptom cluster during dual-target therapy, which negatively affect the quality of life. Medical staffs should formulate management strategies to improve the effect according to the symptom cluster and related factors.