Objective To explore the application and effect of family-centered group volume management in patients with chronic heart failure. Methods A total of 80 patients with chronic heart failure who were hospitalized in the Department of Cardiology of hospital were selected and divided into control group (n=40) and experimental group (n=40) according to the admission time. The control group was given with routine nursing mode,and the experimental group was given with family-centered group volume management mode on the basis of establishing the intervention team, the experimental group was given intervention measures such as interactive and diversified health education, holistic standardized self-management and continuous diversified social support. Results After 6 months,the scores of volume management long-term compliance and medication compliance in experimental group were significantly higher than those in control group,the scores of quality of life (MLHFQ) were lower than those in control group,the 6-minute walking distance,left ventricular ejection fraction and other cardiac functions were significantly higher than those in control group, and the readmission rate was significantly lower than that in control group (P＜0.05). Conclusion The family-centered group volume management model can improve the treatment compliance and cardiac function,improve the quality of life,and reduce the rate of re-hospitalization in patients with chronic heart failure.