Objective To explore the management effect of standards implementation and publicity of Peripheral Venous Indwelling Needle (PVIN) in Chongqing Intravenous Therapy Nursing Alliance (CITNA), and to provide a reference for improving the quality control scheme of intravenous therapy. Methods The management of standards implementation and publicity of PVIN was conducted in 27 tertiary hospitals and 39 second-class hospitals in CITNA, which including point-line-plane three-dimensional training and alliance-district-hospital three-level quality control. A total of 13 984 and 14 040 inpatients were investigated before and after the management to compare the application of PVIN. Results After the management, the proportion of using upper extremity as the puncture site during PVIN insertion increased from 86.63% to 89.31%, the proportion of non-standardized fixation decreased from 26.07% to 13.80%, the non-standardized maintenance rate dropped from 40.84% to 20.58%, the complication incidence associated with PVIN reduced from 10.10% to 7.43%, and the proportion of selecting safety device was significantly higher (all P<0.05). Conclusion The implementation and publicity standards training pattern and quality control management issued by CITNA standardizes the right selection and use of PVIN, facilitates the standardization of PVIN fixation and maintenance, reduces associated complications and promotes the application of safety device.