Objective To explore the effect of artificial respiration with a mask on the ventilation during cardiopulmonary resuscitation, and to provide a reference for expanding the ventilation mode during emergency rescue. Methods A total of 36 members in the emergency care team were selected, then they performed a single cardiopulmonary resuscitation operationon the whole body intelligent manikin model according to the standard guidelines for cardiopulmonary resuscitation, completing 5 standard cycles within 2 minutes, and artificial ventilation was performed mouth-to-mouth during this cycle. Following a rest period of 40 minutes, another cycle of cardiopulmonary resuscitation was performed with artificial ventilation using a medical surgical mask. Objective data regarding chest comprehension and ventilation were collected (including compression depth, compression frequency, and qualified number of ventilation), and the Borg fatigue score and a willingness to choose a ventilation mode were assessed and recorded before and after the operation. Results There weren′t significant differences between the two ventilation methods in terms of qualified ventilation rate or chest compression rate (both P>0.05). As a result of wearing a mask after an operation, the Borg fatigue score was significantly higher than when mouth-to-mouth ventilation was used (P<0.05). When performing cardiopulmonary resuscitation on patients who were receiving artificial ventilation, 94.44% emergency team members were willing to wear masks. Conclusion Wearing a mask for artificial respiration is effective and feasible, it can ensure a satisfactory level of ventilation without compromising the quality of chest comprehension, and it is more readily accepted by medical staff and can improve the operability of cardiopulmonary resuscitation ventilation.