Objective To explore the application effect of comprehensive moxibustion with Huolong Cupping on improving peripheral facial paralysis patients in the acute phase. Methods A total of 80 peripheral facial paralysis patients in the acute phase were randomized into a control group and an experimental group, with 40 cases in each group. Based on conventional treatment, the control group received Moxa-Box moxibustion therapy, while the experimental group received comprehensive moxibustion Huolong Cupping. Before the intervention and 4 weeks after the intervention, the House-Brackmann (H-B) facial nerve function grading scale and the Facial Clinimetric Evaluation (FaCE) scale were utilized to evaluate the facial nerve function and quality of life of the two groups, and the clinical effect of the two groups were assessed after the intervention. Results After the intervention, the H-B grade of the experimental group was significantly lower than that of the control group, and its scores of FaCE scale and subscales, and its clinical effect were significantly better than those of the control group (all P<0.05). Conclusion The comprehensive moxibustion with Huolong Cupping can effectively alleviate the symptoms of peripheral facial paralysis patients in the acute phase, and improve their quality of life and curative effect.