Objective To explore the application effect of family empowerment intervention on primary caregivers of patients with permanent enterostomy. Methods A total of 97 patients with permanent enterostomy and their primary caregivers were selected and divided into a control group of 48 couples and an experimental group of 49 couples chronologically. The control group received conventional care, while the experimental group additionally received a family empowerment intervention. The Caregiver Preparedness Scale (CPS) score, the Sense of Coherence-13 (SOC-13) score, and the Zarit Caregiver Burden Interview (ZBI) score of the caregivers before and after the intervention were compared between the two groups. Results After the intervention, the score of CPS and SOC-13 in the experimental group were significantly higher than those in the control group, and its ZBI score was significantly lower than that of the control group (all P<0.05). Conclusion The family empowerment intervention is conducive to improving the preparedness and sense of coherence in primary caregivers of patients with permanent enterostomy, and it has positive significance to alleviate their caregiving burden.