Objective To explore the application effect of family participatory case management in the health management of overweight or obese patients with polycystic ovary syndrome. Methods A total of 80 patients with overweight or obese polycystic ovary syndrome were divided into a control group and an experimental group chronologically, with 40 cases in each group. The control group received routine health management, while the experimental group was given family participatory case management for 3 months. Results Thirty six patients in the control group and 38 patients in the experimental group completed the study. The results showed that, the time effect, intervention effect and time×intervention effect of BMI, body fat percentage, anxiety and depression scores and the total score of disease-related quality of life in the two groups were significant (all P<0.05), and after the intervention, the BMI, body fat percentage, the scores of anxiety and depression in the experimental group were significantly lower than those in the control group, while its total score of disease-related quality of life scale and the subscale scores of emotional disorder, body weight and menstrual disorder were significantly higher than those in the control group (all P<0.05). Conclusion Family participatory case management can effectively reduce BMI and body fat percentage in patients with overweight or obesity polycystic ovary syndrome, improve their anxiety and depression, and finally improve their quality of life.