Objective To examine the profiles of work-family conflict and enrichment among nurses, and explore the predicting effect of resilience and psychological security, so as to provide empirical evidence for intervention. Methods Totally 470 nurses were surveyed using the Work-Family Conflict Scale, Work-Family Enrichment Scale, Connor-Davidson Resilience Scale and Psychological Safety Scale. The data were analyzed using latent profile analysis and multiple logistic regression analysis. Results Three distinct profiles were identified: enrichment (16.38%), conflicting (19.79%) and slightly conflicting (63.83%). Findings of regression analysis revealed that nurses who had higher resilience and psychological safety were more likely to join the enrichment and slightly conflicting profiles (all P<0.05). Conclusion Work-family interface among nurses is potentially heterogeneous, and resilience and psychological security may be important intervention targets that promote the enrichment of the work-family relationship.