Objective To understand the current situation of kinesiophobia among cancer patients with PICC cathete-rization and explore its influencing factors, so as to provide references for clinical care. Methods The general data questionnaire, the Tampa Scale for Kinesiophobia-11, the Cancer Fatigue Scale and the Simplified Coping Style Questionnaire were used to conduct a cross-sectional survey of 258 patients with PICC catheterization. Results The score of kinetophobia in patients with PICC catheterization was 19.38±4.92, and the incidence of kinetophobia was 53.10%. Multiple linear regression analysis showed that foreign body sensation, cancer-related fatigue, positive coping style and negative coping style were the main influencing factors of kinetophobia in cancer patients with PICC catheterization (all P<0.05). Conclusion The incidence of kinetophobia is high in cancer patients with PICC catheterization. Fear of exercise and its influencing factors should be comprehensively evaluated, and targeted intervention measures should be taken to reduce the level of kinetophobia, so as to reduce potential adverse reactions.