Objective To assess the current status of the occlusion of peripherally inserted central catheter (PICC) placed through the femoral vein, and analyze its influencing factors, so as to provide reference for related nursing measures. Methods The clinical data of 241 patients with femoral vein PICC were retrospectively analyzed, and the influencing factors of catheter blockage were analyzed by univariate and logistic regression. Results Of the patients, 24.07% had catheter blockage. The results of regression analysis showed that the independent risk factors for catheter blockage included catheter dislodgement, first-time catheterization, frequent walking, and the type of PICC (power versus non power injectable) (all P<0.05). Conclusion The incidence of occlusion of PICC placed through the femoral vein is high. In clinical practice, we should pay more attention to the independent risk factors of catheter blockage, and carry out targeted intervention or related health education to reduce the incidence of catheter blockage.