Objective To explore the current situation and influencing factors of decision-making style of decision-makers for patients requiring major cardiovascular surgery, and analyze the correlation between decision-making style and uncertainty tolerance, so as to provide reference for the construction of decision-making scheme in cardiovascular surgery. Methods A total of 192 decision-makers for major cardiovascular surgery were selected and surveyed using the General Decision-Making Style Inventory and Intolerance of Uncertainty Scale-12. Results The decision-making styles of the decision-makers were rational (41.15%), intuitive and impulsive (27.60%), dependent (21.35%) and avoidant (9.90%). Multiple logistic regression analysis showed that decision-makers younger than 60 years old, having a bachelor′s degree or above and monthly per capita household income of 2 000~5 000 yuan, lower scores of prospective emotion and behavior,and whose patients had no need for emergency operation and no comorbidities were more likely to be classified as rational type. Those of patients aged no less than 60 years old tended to be intuitive-impulsive type. Moreover, those with higher prospective emotion score and behavior score, with lower bachelor degree, those whose patients suffering from co-existing diseases and needing emergency surgery, were more likely to be classified as dependent type; decision-makers with higher prospective emotion score, monthly per capita family income >5 000 yuan, and education level below bachelor degree were more likely to be of avoidant style. Conclusion The decision-making styles of decision-makers for major cardiovascular surgery are diverse and vulnerable to many factors. Medical staff should understand their decision-making style based on respect for the decision-makers right to informed consent, make positive guidance according to the influencing factors, and improve their decision-making ability.