Objective To investigate the effect of disease communication on dyadic coping of young couples with gastric cancer based on actor-partner interdependence model （APIM）. Methods A total of 264 couples with gastric cancer were investigated by general situation questionnaire, Cancer-related Communication Problems within Couples Scale and Chinese Version of Dyadic Coping Inventory（CDCI）. Results The disease communication scores of patients with gastric cancer and their spouses were 16（9,25） and 21（8,23）, respectively, and the dyadic coping scores were 128.5（113,138） and 124（99,137）, respectively.The score of treatment specific problem dimension of patients′ disease communication was significantly higher than that of their spouses （P＜0.05）, and the score of stress communication and delegated coping dimensions of dyadic coping were significantly higher than those of their spouses （P＜0.05）.The results of APIM showed that both disease communication could positively affect their own and each other′s dyadic coping （P＜0.05）. Conclusion The dyadic coping of patients with gastric cancer and their spouses was jointly affec-ted by disease communication of the couples, suggesting that medical staff should pay attention to the evaluation of disease communication between couples and actively explore couple-based intervention scheme focusing on disease communication.