Objective To construct an intelligent delivery room childbirth safety checks process, and to explore its application effect. Methods In this quasi-experimental design, 1 445 women who were to have a vaginal birth within January through June 2020, were assigned into the control group and received routine obstetric care after admission; another 1 459 women who were to have a vaginal birth within January through June 2021, were assigned into the intervention group and subjected a closed-loop management mode,in which, an intelligent delivery room childbirth safety checks module, built into HIS and PDA handsets, assisted in the process flow of childbirth safety checks in the delivery room.The incidence rates of postpartum hemorrhage and neonatal asphyxia in the two groups were compared. Results The incidence rate of postpartum hemorrhage in the intervention group was significantly lower than in the control group （P＜0.05）; the incidence rate of neonatal asphyxia in the intervention group was lower than in the control group, with the difference devoid of statistical significance （P＞0.05）. Conclusion The application of intelligent delivery room childbirth safety checks process can effectively reduce postpartum hemorrhage in vaginal delivery, and is of certain significance to prevent neonatal asphyxia.