Abstract: Objective To understand the role of disaster specialist nurses and their perception of clinical practice. Methods The descriptive qualitative approach was used.Semi-structured interviews were conducted with 15 disaster specialist nurses in emergency departments of 3A hospitals in Guangdong.The interview data were analyzed by content analysis method. Results Three themes （perception of disaster specialist nurse role, participation in advanced clinical practice, integration into hospital rescue team construction） and 9 sub-themes were condensed for the work experience of disaster specialist nurses. Conclusion Disaster specialist nurses can play an important role in disaster nursing continuing education, multidisciplinary cooperation and hospital rescue team building. Based on the multidisciplinary characteristics of disaster nursing, hospitals need to specify the role and responsibilities of disaster specialist nurses to fully demonstrate the value of advanced nursing.