Abstract: Objective To understand the progress of "Internet plus nursing service" pilot work in Guangdong Province, and to provide a basis for policy formulation. Methods A total of 177 "Internet plus nursing service" pilot medical institutions were selected to complete a cross-sectional survey using a statistical form designed by the platform of Guangdong Provincial Health Commission, with the contents including the management and service system, operation mechanism and process, and the training system of nurses.The statistical form was filled out by the director of nursing department of the pilot institution. Results A total of 146 pilot institutions actually carried out the work of "Internet plus Nursing Service"; among the institutions, tertiary hospitals accounted for 58.90%.A total of 13,154 nurses participated in the service, and the total number of visits was 192,442.The average patient satisfaction was 96.63%, and the overall satisfaction of nurses was 88.67%.There were 43 "Internet plus nursing service" items, among which the items with the highest visits were maternal and infant nursing （44,074 visits）, vital signs monitoring （23,313 vi-sits） and home inspection （21,636 visits）, and the items with the lowest visits were colostomy bag related care (16 visits) and enema care (16 visits). Conclusion The pilot work of "Internet plus nursing service" in Guangdong province has achieved preliminary results.The service mode conforming to the actual situation of the province has been preliminarily formed.However, it is still ne-cessary to expand the service population, supplement the service items, optimize the payment mechanism and strengthen the supervision system.