Objective To explore the effect of establishing a pediatric epilepsy nursing team in clinical practice. Methods A historical control design was adopted.A total of 502 children admitted in 2018 were taken as the control group, and received routine care provided by their charge nurse.Another 487 children admitted in 2021 were taken as the intervention group, and were managed by a pediatric epilepsy nursing team on top of routine care.The nursing quality and nursing adverse events were compared between the 2 groups. Results The nursing quality during seizure onset of the intervention group was significantly higher than that of the control group (all P＜0.05).The intervention group had fewer nursing adverse events than the control group; among the events, the intervention group had significantly lower incidence rate of pressure injury in the head than the controls (P＜0.05). Conclusion The establishment of pediatric epilepsy nursing team group can effectively improve the quality of nursing care during seizure onset, ensure nursing safety, and improve the care outcome.