Objective To study the effects of micro-lecture on self-care ability, daily living ability, and psychological status of postdischarge patients with spinal cord injury (SCI). Methods A total of 72 postdischarge SCI patients were randomized into a control group and an intervention group, with 36 in each group. The control group was given routine health education and telephone follow-ups, while the intervention group received micro-lectures for instructing rehabilitation at home for 6 months.The Self-care Agency Scale, Barthel Index, Self-rating Anxiety scale, Self-rating Depression Scale, and self-designed patient satisfaction questionnaire were utilized to measure the effect before discharge and at 1,3, 6 months post discharge. Results Finally, 35 patients in the control group and 34 in the intervention group completed the study. The intervention group had significantly higher self-care agency, daily living ability and satisfaction, whereas lower anxiety and depression at 6 months post discharge than the control group (all P<0.05). Conclusion Micro-lecture for health education can improve self-care agency and daily living ability of postdischarge SCI patients, and alleviate their negative emotions.