Objective To investigate the effect of multimodal exercise in colorectal cancer patients with chemotherapy-induced peripheral neuropathy （CIPN）. Methods A total of 82 colorectal cancer patients with CIPN were conveniently selected and divided into a control group and an intervention group, with 41 in each group. The control group was asked to walk for 30 min per session, at least 3 sessions per week. The intervention group received multimodal exercise with a time commitment of 30-40 min per session, at least 3 sessions per week. The CIPN Assessment Tool (CIPNAT), Berg Balance Scale (BBS), Modified Falls Efficacy Scale (MFES), and Timed Up and Go Test (TUGT) were utilized to compare the effect between the two groups before and after 12-week intervention. Results Thirty-eight in the control group and 36 in the intervention group completed the study. After 12 weeks of intervention, the CIPNAT score，the incidence of BBS score <45, and TUGT test result were significantly lower, whereas MFES score was significantly higher in the intervention group compared with the control group (all P<0.05). Conclusion Multimodal exercise can alleviate symptom experience of CIPN and its impact on daily living in colorectal cancer patients, and enhance their balance function, falls self-efficacy and mobility.