Objective To explore the effect of nurse-led swallowing training on swallowing function and prognosis of patients with post-extubation dysphagia (PED). Methods A total of 62 patients with PED were randomly divided into control group (30 cases) or intervention group (32 cases). The control group received routine dysphagia diet and relevant health guidance, while patients in the intervention group additionally received nurse-led swallowing training for five consecutive days. The swallowing function, oral feeding and complications were observed in both groups before and after the intervention. Results After the intervention, the intervention group presented significantly lower standardized swallowing assessment (SSA) score， higher swallowing function recovery rate, shorter swallowing function recovery time， higher functional oral intake grade, and lower incidence of food residue and aspiration compared to the control group (all P＜0.05). Conclusion Nurse-led swallowing training can promote the recovery of swallowing function, thus to facilitate oral feeding and improve the prognosis of patients.