Objective To understand medical staffers′ perspective on the barriers and facilitators during implementation of targeted temperature management evidence summarized for patients with traumatic brain injury （TBI）, and to provide references for clinical evidence-based nursing practice. Methods Semi-structured interviews were conducted in 7 nurses and 3 doctors working in neurosurgical ICU. Then interview data were sorted and analyzed per content analysis method. Results The three themes of evidence, organizational environment, and facilitators were extracted, totaling 8 sub-themes which included: some evidence did not fully consider the clinical context; the evidence failed to gain confidence from medical staff and evidence information was asymmetrical; the head nurses needed to further sort out the specific role of leadership in evidence transformation; there was increased workload in the early stage of change, but the practice team had positive attitude; strictly following evidentiary requirements were the difficulties in practice； nurses trusted the evidence and were willing to take action; the establishment of a department-level management team was a strong guarantee for the implementation of the change; special management and effectiveness promoted the implementation of the change. Conclusion Nursing managers should develop and improve relevant assessment tools and processes, and pay attention to the important role of organizational environment in the duration of project implement, so as to push forward clinical implement of targeted temperature management evidence summarized for TBI patients.