Objective To explore the implementation effect of family integrated transitional care for discharged head and neck cancer patients carrying tube after tracheotomy. Methods A total of 78 discharged head and neck cancer patients carrying tube after tracheotomy were randomized into an intervention group and a control group, with 39 cases in each group. The control group received routine discharge guidance and health education, while the intervention group additionally implemented family integrated transitional care, which including training family members the skills of nursing after tracheotomy, and providing out-of-hospital transitional care guidance to the patients and their families through the Internet. The nursing skill level of tracheotomy and home care ability of the family members and the incidence of tracheotomy-related complications and the readmission rate of the two groups were compared. Results At discharge, the evaluation score of tracheotomy-related nursing skills in family members in the intervention group was significantly higher than that in the control group, and there was a significant difference in their scores of home care ability at discharge, 1 month and 3 months after discharge (P<0.05 for all). In addition, 3 months after discharge, the incidence of tracheotomy-related complications and readmission rate in the intervention group were significantly lower than those in the control group (P<0.05 for both). Conclusion Family integrated transitional care provides continuous, high-quality and professional home care support for discharged head and neck cancer patients carrying tube after tracheotomy, which can improve the home care ability of family caregivers and effectively reduce the incidence of complications.