Objective To investigate the levels of posttraumatic growth, resilience, and quality of life of patients with chronic diseases, and to explore the relationship among them. Methods A total of 294 patients with chronic diseases were selected by convenience sampling method and surveyed using a self-designed general information questionnaire, the Posttraumatic Growth Inventory, 14item Resilience Scale and 12-item Short-Form Health Survey. Results The median scores of posttraumatic growth, resilience, and quality of life were 61.0 （IQR:51.0-70.0）, 71.0 （IQR:60.0-81.0）, and 50.8 （IQR:37.5-65.6）, respectively. Posttraumatic growth was positively correlated with resilience and quality of life, and resilience was also positively correlated with quality of life （all P＜0.05）.Resilience fully mediated the relationship between posttraumatic growth and quality of life （P＜0.05）. Conclusion Patients with chronic diseases report moderate levels of posttraumatic growth, resilience, and quality of life.Posttraumatic growth can affect quality of life of patients through resilience. Medical staff should take measures to enhance post-traumatic growth and psychological resilience of patients with chronic diseases, thus to improve their quality of life.